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A computer model simulating human glucose absorption and metabolism in health and metabolic disease states

The roles of apical SGLT1 and GLUT2 intestinal glucose absorption The sodium dependent glucose transporter SGLT1 is the only active component of intestinal transport sugar absorption. When SGLT1 is deficient, as in glucose-galactose malabsorption syndrome 1 – 3 , or inactivated by specific inhibitors, such as phloridzin, or similarly acting high efficacy inhibitors e.g. GSK1614235 4 , small intestinal sugar absorption is blocked and the ingested sugar load is relegated to the large intestine where it becomes subject to fermentation processes. It has been argued that exposure to high intestinal luminal glucose concentrations ≥ 15mM, or more modest glucose loads, supplemented with artificial sweeteners, induces small intestinal apical membrane passive glucose transport via GLUT2 5 , 6 . This process is stimulated by enterocyte AMP kinase(AMPK), triggered by opening of Cav 1.3 Ca 2+  channels following SGLT1-dependent depolarization of the apical membrane potential 7 . However, wh
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Cause and age-related mortality trends in Bangladesh (2000-2008)

Mortality trends are important to demographers because they present a useful way of examining mortality differentials and their principal causes across populations. It has been reported that generally mortality rates in Bangladesh have reduced notably over recent decades 1 . However, deaths caused by chronic diseases are rising at an alarming rate 1 . There is a rapid rise observed in the burden of non-communicable diseases (NCDs) worldwide. Demographic transition and changing lifestyles among people are important factors for these kind of health problems 2 . The World Health Organization (WHO) has predicted that, by 2020, two-thirds of the world’s global burden of disease will be caused by non-communicable conditions 3 . In 2005 it was reported that non-communicable diseases such as heart disease, stroke,  diabetes   mellitus , cancer, and chronic respiratory diseases were responsible for 59% of the 57 million deaths yearly and 46% of the total burden of disease, globally 3 . Th
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